Splenectomy in myeloid metaplasia
نویسندگان
چکیده
منابع مشابه
Splenectomy in myeloid metaplasia.
Between 1960 and 1977, 50 patients with agnogenic myeloid metaplasia were splenectomized. Twenty-five of 26 patients with painful splenomegaly, 4 of 9 patients with refractory hemolytic anemia, 4 of 10 patients with refractory thrombocytopenia, and 4 of 4 patients with portal hypertension showed significant benefit from the procedure. There were five immediate postoperative deaths. Four of thes...
متن کاملAgnogenic myeloid metaplasia: role of splenectomy.
The splenomegaly associated with myelofibrosis and agnogenic myeloid metaplasia should not be considered a manifestation of the fundamental proliferative process, nor should it be considered as necessarily compensatory for reduced marrow haematopoiesis. In deserving cases splenectomy may cause an improvement in the patient's general and haematopoietic status. Removal of the source of functional...
متن کاملSplenectomy in agnogenic myeloid metaplasia: factors of possible prognostic significance.
The available data of 338 cases of splenectomy in agnogenic myeloid metaplasia published since 1940 were retrieved from the literature and analysed. Postoperative survival was significantly shorter in patients with anaemia, massive splenomegaly or elevated serum alkaline phosphatase. Younger age or normal platelet counts were associated with a longer postoperative survival than that in older pa...
متن کاملSplenectomy and risk of blast transformation in myelofibrosis with myeloid metaplasia. Italian Cooperative Study Group on Myeloid with Myeloid Metaplasia.
An unexpectedly high incidence of blast transformation after splenectomy has been reported in patients with myelofibrosis with myeloid metaplasia. However, whether this was associated with spleen removal after adjustment for risk factors was not determined. We conducted a multicenter historical cohort study of patients with myelofibrosis with myeloid metaplasia diagnosed from January 1970 throu...
متن کاملSplenectomy in myelofibrosis with myeloid metaplasia: a single-institution experience with 223 patients.
In a 20-year period, 223 patients (median age, 64.8 years) with myelofibrosis with myeloid metaplasia (MMM) had therapeutic splenectomy at our institution. Primary indications for surgery were transfusion-dependent anemia (45.3%), symptomatic splenomegaly (39. 0%), portal hypertension (10.8%), and severe thrombocytopenia (4.9%). Operative mortality and morbidity rates were 9% and 31%, respectiv...
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ژورنال
عنوان ژورنال: Blood
سال: 1979
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v53.3.515.515